EAnnatto Tocotrienol World Best Vitamin E
Have all those conventional treatments failed when it comes
to tackling high cholesterol, stiff arteries, diabetes, cancer and other
chronic ailments? If yes, then cheer up a bit because now you’ve got an “ace up
your sleeve”!
Introduction
So what is that “Ace”? No, it is not those conventional
chemotherapies, radiation or surgery. The “Ace up your sleeve” is just the
correct Vitamin E! You are well aware of the benefits of vitamins in your
daily life and you know they can work wonders in preventing and treating
several diseases. Vitamins have already been observed to have anti-aging
benefits, heart diseases, inflammation and lower the risk of cancer. But
there’s a trick to taking your vitamins – and it’s one that too many people
don’t know about. Conventionally, people have been just popping multi-vitamins
daily which is not enough to help you beat the odds against those deadly
diseases. In fact, certain vitamins need to be combined with others in order to
work better. On their own, they are not of much use. Well, this is not the same
in case of all vitamins.
Some vitamins are sometimes isolated to unleash their full
potential and this case is very much applicable to as I mentioned above, the
“correct Vitamin E”. Well you surely haven’t heard of this unappreciated
Vitamin E which has been identified for its beneficial effects against
cardiovascular diseases and cancer. And guess what? You can give them both a
tough fight with this “correct Vitamin E” the “Ace up your sleeve” – Tocotrienol!
Tocotrienol has been an unsung hero for several decades
whose capabilities have been overshadowed by Tocopherol. But what’s Tocopherol?
It may surprise you that Vitamin E is not just one Vitamin E but a family of
different vitamins. In fact, there are two types of compounds within the
Vitamin E family, called Tocopherols and Tocotrienols. Tocopherol is the
Vitamin E which you have been consuming every day in your daily diet and
multivitamins and it has also been observed that Tocopherols barely play any
role against diseases like cancer and CVDs. Moreover, in several studies,
Tocopherols have been observed to hinder the functioning of Tocotrienol against
cancers and CVDs and even harm your body in certain ways!
The unappreciated
Tocotrienol and the overestimated Tocopherol
Tocotrienol has been unappreciated for decades even after
its discovery. Dr. Barrie Tan, who has been studying Vitamin E since 35 years,
discovered Tocotrienols derived from the Annatto plantand also
found that Annatto plant was the only one which contained 100% Tocotrienol and
0% Tocopherol unlike rice bran and palm oils which do have Tocotrienols but a
very high percentage of Tocopherol. Tocopherols, on the other hand, can be
found in sufficient quantity in your food and your daily diet and multivitamins
are mainly composed of Alpha-Tocopherols
Tocotrienol Sources
& Composition
Tocopherol has a structure composed of a head with an OH
group and a saturated tail while Tocotrienol has three double bonds, is
unsaturated and has a head smaller than Tocopherol. Tocopherol also is larger
in size and has a higher molecular weight than Tocotrienol due to which
Tocopherols have very low mobility and are unable to target more cells.
Tocotrienols, on the other hand, have very high anti-oxidant activities
due to their small structure and less molecular weight which assists in their
integration of the cell, unlike Tocopherols. Moreover, it has been found that
Tocotrienols are approximately 50 times more potent than Tocopherols! If
you are like other people, then probably you too are consuming Tocopherols and
not Tocotrienols in your supplements. Consumption of Tocopherols in
supplements must be discouraged as research has shown that supplementing
Alpha-Tocopherol interferes with the tissue delivery of certain Tocotrienols.
And if you are concerned about cardiovascular studies, cancers and so on, you
must keep reading this blog. And also, for several decades, the majority of
research has been focused on Alpha-Tocopherol whereas only 3% of the study has
been conducted on Tocotrienol. However clinical studies have significantly
proven that Tocotrienols display stronger anti-oxidant, anti-inflammatory, and
chemopreventive activities than Tocopherol based Vitamin E.
Cardiovascular
benefits of Tocotrienols – A new beginning for your heart
For several years, antioxidants have been associated with
both the reduction in cardiovascular diseases and the inhibition of cancer. In
2001, researchers tested Tocotrienols for their ability in reducing plaque
buildup in arteries. This four-year study from Elmhurst Medical Center in
Queens, New York, involved 50 participants who had the plaque in their carotid
arteries, the major arteries that carry blood to the brain. Among the
participants who took 240 mg of Tocotrienols a day along with 60 mg
of Alpha-Tocopherols, an amazing 88% experienced either no increase in plaque
or even reduction in plaque. But, the participants taking a placebo, 80% of
them experienced a worsening in their condition. In a study conducted in
2015, several people with high cholesterol took supplements ranging from
125-750 mg/day of Tocotrienols for 4 weeks. It was observed that on average,
total cholesterol levels were lowered by 15 percent LDL cholesterol dropped by
18% and triglycerides decreased by 14%. The levels of inflammatory chemicals
associated with cardiovascular diseases, called cytokines, were also reduced –
and by a whopping 64%! Other kinds of research have also shown that when Tocotrienols
were combined with plant-derived anti-oxidant polyphenols, Delta-Tocotrienol (One
of the four forms of Tocotrienols) reduced inflammation and lowered lipids
associated with atherosclerosis.
Scientists from the University of Missouri – Kansas City
reported that Tocotrienol doses ranging from 125 – 750 mg/day combined with the
healthy diet decreased lipid levels significantly after only 4 weeks.
Other features of Tocotrienol observed were
·
Cholesterol reduction is a significant
feature of Tocotrienols by suppression of HMGR (3-hydroxy3methyl-glutaryl-CoA
reductase) the enzyme/protein responsible for the body’s cholesterol
production.
·
Cytokines associated with cardiovascular
diseases were down-regulated by Tocotrienols according to the study done at the
University of Missouri – Kansas City.
·
MicroRNAs which are usually down-regulated
in hyper-cholesterolemic individuals are up-regulated by Tocotrienol treatment
as per the study.
·
Cellular adhesion molecule expression has
been observed to be reduced by Tocotrienols.
·
Monocytic cell adherence has also been
found to be reduced by Tocotrienol in multiple kinds of research.
·
‘Velcro effect’, a process which initiates
plaque formation in arterial walls has also been observed to be reduced by
Tocotrienol.
·
Lipid peroxides in blood vessels and blood
pressure have been observed to be lowered by Tocotrienols which improves total
anti-oxidant status thus preventing hypertension
·
Carotid Arteriosclerosis has been observed
to be reduced by Tocotrienol in several studies
Fight your cancer more effectively with
Tocotrienol
Tocotrienols have been observed to have several
anti-cancer benefits. They have been observed to reduce inflammation which is
quite important since inflammation encourages tumor growth. Also, Tocotrienols
have been observed to reduce chronic inflammation by decreasing an inflammatory
protein connected with cancer called Nf-kB, as well as other biomarkers. To
know further about the anti-cancer activities of Tocotrienol, you must know
terms related to cancer first and the effects of Tocotrienol related to them.
Annatto based
Tocotrienol (Eannatto) which
has been observed to possess anti-cancer activities in another study,
‘Down-regulation of telomerase activity in DLD-1 human colorectal
adenocarcinoma cells by Tocotrienol’ was conducted in which it was also
observed that it was observed that Tocotrienol inhibited telomerase activity of
DLD-1 human colorectal adenocarcinoma cells in time- and dose-dependent manner.
Interestingly Delta-Tocotrienol was observed to exhibit the highest inhibitory
activity.
In Prostate Cancer, Delta and Gamma-Tocotrienols, in
particular, were shown to inhibit several types of prostate cancer cell lines.
While Delta-Tocotrienol most effectively induced cell death of prostate cancer
cells and activated programmed cell death while disrupting NF-kB signaling,
Gamma-Tocotrienol also suppressed prostate cancer in vitro and in vivo.
Anti-cancer activities of Tocotrienols have been observed in
several kinds of research against all sorts of cancers like lung cancer, liver
cancer, ovarian cancer, prostate cancer, glioblastoma and so on.
Other benefits of Tocotrienol
·
Delta-Tocotrienol has been observed to improve
Fatty Liver in Non-Alcoholic Fatty Liver disease which is usually associated with
obesity and metabolic syndrome.
·
Tocotrienols have also been observed to suppress
diseases like Hepatitis C.
·
Tocotrienols have also been observed to delay
Cataract Progression and Cataractogenesis.
·
Tocotrienols have also been observed to suppress
Alzheimer’s disease.
· \ Tocotrienols have also been observed to
mineralize bones and it has also been shown in several kinds of research that
animals with Tocotrienol handled stress and load at fractures site. Tocotrienol
was also shown to prevent fracture recurrence. They also restored callus stiffness
to normal levels
Conclusion
You must not make this common mistake of consuming Vitamin-E
which is “incomplete”. Americans consume about 70% of their vitamin E as
Gamma-Tocopherols due to their abundance in corn- and soy-based foods and
several vegetable oils in their diets. Henceforth supplementation of
Tocopherols is a serious mistake which you must not make. Tocotrienol is rare
and almost all foods lack the required quantity of Tocotrienol except Annatto
which is one of the highest food sources of Tocotrienols. Owing to such
qualities against deadly diseases like CVD and cancer, Tocotrienol
supplementation is just as it not only helps you prevent them but also helps in
suppressing them.
· Angiogenesis or formation of blood vessels
in cancer cells promotes cancer cell growth to a very great extent. Tocotrienol
is a master of anti-angiogenesis.
·
Apoptosis or programmed cell death is the
process of elimination and death of cancer cells. Tocotrienol induces apoptosis
in cancer cells by increasing endoplasmic reticulum stress and autophagy thus
helping in killing cancer cells.
·
Cell Proliferation is the process by which
cancer cells copy their DNA and divide into two cancer cells during mitosis and
rapidly multiply into more cancer cells. According to several kinds of
research, it has been proven that alpha, gamma, and delta Tocotrienols suppress
the proliferation of cancer cells.
·
Chemoprevention and anti-cancer activities
are some characteristic qualities of Tocotrienol.
·
Chemosensitization is the combination of
Tocotrienol with several chemotherapeutic drugs such as celecoxib, statins or
dietary components such as curcumin, polyphenols, etc. which effectively
sensitize the cancer cells.
· Stem cells of the remaining 1% cancer cells
which are never affected by chemotherapy and radiation and are traveling
throughout the body which is also the main reason of reoccurrence of cancer
even after those conventional treatments, has shown to be eliminated by
Tocotrienol in the research.
·
Tumor nutrition can also be obstructed by
Tocotrienol as they may well work on dual antitumor mechanisms that include the
removal of the vital nutrient to tumor lifeline.
Several studies have been conducted on Tocotrienol to
observe its anti-cancer effects and one such study ‘miR-429 mediates Delta-Tocotrienol induced
apoptosis in triple-negative breast cancer (TNBC) cells by targeting XIAP’ was
conducted where the effects of Delta-Tocotrienol on exponentially growing TNBC
cells, MDA_MB-231 and MDAMB-468 cells, also known as human triple negative
breast cancer cells were treated in the presence of Delta-Tocotrienol for 24
hours, and the cell viability rate was measured using an MTT assay. It was
observed that treatment with Delta-Tocotrienol inhibited the proliferation of
MDA-MB-231 and MDA-MB-468 cells in a dose-dependent manner.
In one other study, ‘First Evidence
That Gamma-Tocotrienol Inhibits the Growth of Human Gastric Cancer
and Chemosensitizes it to Capecitabine in a Xenograft Mouse Model through the
Modulation of NF-kB Pathway’ where it was observed that Tocotrienol could
potentiate the effects of capecitabine through suppression of NF-kB-regulated
markers of proliferation, invasion, angiogenesis, and metastasis.
References
· Tocotrienols: The Promising Analogues of Vitamin
E for Cancer Therapeutics
·
Annato: Delivering Tocotrienols from Amazonia,
by Barrie Tan, Founder, &Anne Trias, Product Director
·
Tocotrienols: Vitamin E for Cardiovascular
benefits after all by Barrie Tan, Ph.D., and Anne M. Trias, MS.
·
Delta-tocotrienol inhibits non-small-cell lung
cancer cell invasion via the inhibition of NF-κB, uPA activator, and MMP-9.
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